Cytogenetics Influences of Domperidone on Male Mice Mus Musculus

Nuha Hussam Abdulwahab
Biology Department
Faculty of Education for Pure science
Tikrit University, Iraq
 عنوان البريد الإلكتروني هذا محمي من روبوتات السبام. يجب عليك تفعيل الجافاسكربت لرؤيته. 

 Lamyaa Khames. Naif
Biology Department
 Faculty of Sciences
 Tikrit University,  Iraq
 عنوان البريد الإلكتروني هذا محمي من روبوتات السبام. يجب عليك تفعيل الجافاسكربت لرؤيته. 

Reem Saud Abed
Faculty of Physical Education
Tikrit University,  Iraq
 عنوان البريد الإلكتروني هذا محمي من روبوتات السبام. يجب عليك تفعيل الجافاسكربت لرؤيته.

Keywords: Domperidone, Mitotic index test, Micronucleus test

 Abstract
   Domperidone is drug has opposing effects to dopamine and has different pharmaceutical benefits, like vomiting trigger zone inhibition , relaxation of smooth muscle and stimulating lactation. This study aimed to estimate toxicity of domperidone by using mitotic index and micronucleus tests. These tests were served as indicators to investigate Domperidone cytotoxicity and genotoxicity in male mice. In  this research we can concluded that domperidone inhibits  cell growth, reduce cell viability and has no potential genotoxic effect. Domperidone caused  anoticeable decrease in mitotic index and no strong effect on micronuclei